摘 要
随着口腔修复材料的广泛应用，其对牙周组织的影响成为研究热点。本研究旨在探讨不同口腔材料对牙周组织的生物学效应，为临床应用提供理论依据。选取健康成年比格犬12只，随机分为4组，每组3只，分别植入钛合金、氧化锆、玻璃陶瓷和树脂四种常见口腔材料，建立实验模型。通过组织学观察、细胞因子检测等方法，在术后1、2、4、8周取材分析。结果显示，钛合金和氧化锆组牙周组织炎症反应轻微，新生血管丰富，成纤维细胞增殖活跃；玻璃陶瓷组早期出现轻度炎症，但后期逐渐恢复；树脂组则表现出持续性炎症反应，牙龈上皮增生明显。创新点在于首次系统比较了多种常用口腔材料在同一动物模型中的长期生物相容性，发现金属与非金属材料在牙周组织反应上存在显著差异，其中钛合金和氧化锆表现出更优的生物相容性。本研究为优化口腔材料选择提供了重要参考，强调了材料表面特性对牙周组织影响的重要性，为后续相关研究奠定了基础。
关键词：口腔材料；牙周组织反应；生物相容性
Abstract
With the widespread application of dental restorative materials, their impact on periodontal tissues has become a research hotspot. This study aims to investigate the biological effects of different dental materials on periodontal tissues, providing theoretical evidence for clinical applications. Twelve healthy adult Beagle dogs were randomly divided into four groups, with three dogs in each group, and titanium alloy, zirconia, glass ceramic, and resin, four common dental materials, were respectively implanted to establish experimental models. Materials were collected at 1, 2, 4, and 8 weeks post-surgery for analysis through histological observation and cytokine detection. The results showed that the titanium alloy and zirconia groups exhibited mild inflammatory responses in periodontal tissues, abundant neovascularization, and active fibroblast proliferation; the glass ceramic group displayed mild inflammation in the early stage but gradually recovered later; the resin group showed persistent inflammatory reactions with significant hyperplasia of gingival epithelium. The innovation lies in systematically comparing the long-term biocompatibility of multiple commonly used dental materials in the same animal model for the first time, revealing significant differences in periodontal tissue responses between me tallic and non-me tallic materials, with titanium alloy and zirconia demonstrating superior biocompatibility. This study provides crucial references for optimizing the selection of dental materials, emphasizing the importance of material surface characteristics on periodontal tissues, and laying a foundation for subsequent related research.
Keywords：Dental Materials；Periodontal Tissue Response；Biocompatibility
目 录
引 言 1
第一章 口腔材料的分类与特性 2
1.1 口腔材料的主要类型 2
1.2 材料的物理化学性质 2
1.3 材料的生物相容性评价 3
第二章 牙周组织的结构与功能 5
2.1 牙周组织的解剖特点 5
2.2 牙周组织的生理功能 5
2.3 牙周组织的免疫反应 6
第三章 实验设计与方法 8
3.1 实验动物与样本选择 8
3.2 材料植入手术过程 8
3.3 观察指标与检测方法 9
第四章 实验结果与分析 10
4.1 不同材料对牙龈影响 10
4.2 对牙周膜的作用效果 10
4.3 对牙槽骨的影响差异 11
结 论 12
参考文献 13
致 谢 14
随着口腔修复材料的广泛应用，其对牙周组织的影响成为研究热点。本研究旨在探讨不同口腔材料对牙周组织的生物学效应，为临床应用提供理论依据。选取健康成年比格犬12只，随机分为4组，每组3只，分别植入钛合金、氧化锆、玻璃陶瓷和树脂四种常见口腔材料，建立实验模型。通过组织学观察、细胞因子检测等方法，在术后1、2、4、8周取材分析。结果显示，钛合金和氧化锆组牙周组织炎症反应轻微，新生血管丰富，成纤维细胞增殖活跃；玻璃陶瓷组早期出现轻度炎症，但后期逐渐恢复；树脂组则表现出持续性炎症反应，牙龈上皮增生明显。创新点在于首次系统比较了多种常用口腔材料在同一动物模型中的长期生物相容性，发现金属与非金属材料在牙周组织反应上存在显著差异，其中钛合金和氧化锆表现出更优的生物相容性。本研究为优化口腔材料选择提供了重要参考，强调了材料表面特性对牙周组织影响的重要性，为后续相关研究奠定了基础。
关键词：口腔材料；牙周组织反应；生物相容性
Abstract
With the widespread application of dental restorative materials, their impact on periodontal tissues has become a research hotspot. This study aims to investigate the biological effects of different dental materials on periodontal tissues, providing theoretical evidence for clinical applications. Twelve healthy adult Beagle dogs were randomly divided into four groups, with three dogs in each group, and titanium alloy, zirconia, glass ceramic, and resin, four common dental materials, were respectively implanted to establish experimental models. Materials were collected at 1, 2, 4, and 8 weeks post-surgery for analysis through histological observation and cytokine detection. The results showed that the titanium alloy and zirconia groups exhibited mild inflammatory responses in periodontal tissues, abundant neovascularization, and active fibroblast proliferation; the glass ceramic group displayed mild inflammation in the early stage but gradually recovered later; the resin group showed persistent inflammatory reactions with significant hyperplasia of gingival epithelium. The innovation lies in systematically comparing the long-term biocompatibility of multiple commonly used dental materials in the same animal model for the first time, revealing significant differences in periodontal tissue responses between me tallic and non-me tallic materials, with titanium alloy and zirconia demonstrating superior biocompatibility. This study provides crucial references for optimizing the selection of dental materials, emphasizing the importance of material surface characteristics on periodontal tissues, and laying a foundation for subsequent related research.
Keywords：Dental Materials；Periodontal Tissue Response；Biocompatibility
目 录
引 言 1
第一章 口腔材料的分类与特性 2
1.1 口腔材料的主要类型 2
1.2 材料的物理化学性质 2
1.3 材料的生物相容性评价 3
第二章 牙周组织的结构与功能 5
2.1 牙周组织的解剖特点 5
2.2 牙周组织的生理功能 5
2.3 牙周组织的免疫反应 6
第三章 实验设计与方法 8
3.1 实验动物与样本选择 8
3.2 材料植入手术过程 8
3.3 观察指标与检测方法 9
第四章 实验结果与分析 10
4.1 不同材料对牙龈影响 10
4.2 对牙周膜的作用效果 10
4.3 对牙槽骨的影响差异 11
结 论 12
参考文献 13
致 谢 14
