猫下泌尿道综合征的病因分析与治疗进展
摘 要
猫下泌尿道综合征（Feline Lower Urinary Tract Disease, FLUTD）是兽医学领域中一种常见且复杂的疾病，其病因多样且病理机制尚未完全明确。本研究旨在系统分析FLUTD的潜在病因，并探讨当前治疗策略的进展与局限性。通过回顾性分析临床病例数据、实验室检测结果及影像学检查资料，结合分子生物学技术对病原体进行鉴定和分类，进一步揭示了FLUTD的多因素致病机制。研究发现，尿路感染、尿结石、功能性膀胱疾病及环境压力是FLUTD的主要诱因，其中环境因素的作用被显著低估。在治疗方法上，除传统抗生素和手术干预外，本研究创新性地引入了基于肠道-泌尿道轴的微生物调节疗法，显著改善了部分患者的预后。此外，研究还提出了一种综合评估模型，用于早期预测高风险个体并制定个性化治疗方案。综上所述，本研究不仅深化了对FLUTD病因的认识，还为临床诊疗提供了新的思路和技术支持，具有重要的理论和实践意义。
关键词：猫下泌尿道综合征；病因机制；肠道-泌尿道轴
ETIOLOGICAL ANALYSIS AND THERAPEUTIC ADVANCES IN FELINE LOWER URINARY TRACT SYNDROME
ABSTRACT
Feline Lower Urinary Tract Disease (FLUTD) is a common and complex condition in the field of veterinary medicine, characterized by diverse etiologies and incompletely understood pathogenic mechanisms. This study aims to systematically analyze the potential causes of FLUTD and evaluate the advancements and limitations of current treatment strategies. By conducting a retrospective analysis of clinical case data, laboratory test results, and imaging examination materials, combined with molecular biological techniques for pathogen identification and classification, this research further elucidates the multifactorial etiology of FLUTD. The findings indicate that urinary tract infections, urolithiasis, functional bladder diseases, and environmental stress are the primary triggers of FLUTD, with the role of environmental factors being significantly underestimated. In terms of treatment, in addition to traditional antibiotics and surgical interventions, this study innovatively introduces microbiota-modulating therapy based on the gut-urinary axis, which markedly improves the prognosis of some patients. Furthermore, a comprehensive evaluation model is proposed to predict high-risk individuals at an early stage and develop personalized treatment plans. In summary, this study not only enhances the understanding of FLUTD etiology but also provides new insights and technical support for clinical diagnosis and treatment, holding significant theoretical and practical implications.
KEY WORDS：Cat Lower Urinary Tract Syndrome；Etiological Mechanism；Gut-Urinary Axis
目 录
摘 要 I
ABSTRACT II
第一章 绪论 1
1.1 研究背景与意义 1
1.2 国内外研究现状分析 1
第二章 猫下泌尿道综合征的病因分析 2
2.1 解剖与生理基础概述 2
2.2 常见病因分类与机制 2
2.3 特殊病因的识别与评估 3
第三章 猫下泌尿道综合征的诊断技术进展 4
3.1 临床症状与初步诊断 4
3.2 实验室检测技术的应用 4
3.3 影像学检查在诊断中的作用 5
第四章 猫下泌尿道综合征的治疗策略与进展 6
4.1 药物治疗的选择与优化 6
4.2 手术干预的适应症与效果 6
4.3 预防措施与长期管理方案 7
结 论 8
参考文献 9
致 谢 10
摘 要
猫下泌尿道综合征（Feline Lower Urinary Tract Disease, FLUTD）是兽医学领域中一种常见且复杂的疾病，其病因多样且病理机制尚未完全明确。本研究旨在系统分析FLUTD的潜在病因，并探讨当前治疗策略的进展与局限性。通过回顾性分析临床病例数据、实验室检测结果及影像学检查资料，结合分子生物学技术对病原体进行鉴定和分类，进一步揭示了FLUTD的多因素致病机制。研究发现，尿路感染、尿结石、功能性膀胱疾病及环境压力是FLUTD的主要诱因，其中环境因素的作用被显著低估。在治疗方法上，除传统抗生素和手术干预外，本研究创新性地引入了基于肠道-泌尿道轴的微生物调节疗法，显著改善了部分患者的预后。此外，研究还提出了一种综合评估模型，用于早期预测高风险个体并制定个性化治疗方案。综上所述，本研究不仅深化了对FLUTD病因的认识，还为临床诊疗提供了新的思路和技术支持，具有重要的理论和实践意义。
关键词：猫下泌尿道综合征；病因机制；肠道-泌尿道轴
ETIOLOGICAL ANALYSIS AND THERAPEUTIC ADVANCES IN FELINE LOWER URINARY TRACT SYNDROME
ABSTRACT
Feline Lower Urinary Tract Disease (FLUTD) is a common and complex condition in the field of veterinary medicine, characterized by diverse etiologies and incompletely understood pathogenic mechanisms. This study aims to systematically analyze the potential causes of FLUTD and evaluate the advancements and limitations of current treatment strategies. By conducting a retrospective analysis of clinical case data, laboratory test results, and imaging examination materials, combined with molecular biological techniques for pathogen identification and classification, this research further elucidates the multifactorial etiology of FLUTD. The findings indicate that urinary tract infections, urolithiasis, functional bladder diseases, and environmental stress are the primary triggers of FLUTD, with the role of environmental factors being significantly underestimated. In terms of treatment, in addition to traditional antibiotics and surgical interventions, this study innovatively introduces microbiota-modulating therapy based on the gut-urinary axis, which markedly improves the prognosis of some patients. Furthermore, a comprehensive evaluation model is proposed to predict high-risk individuals at an early stage and develop personalized treatment plans. In summary, this study not only enhances the understanding of FLUTD etiology but also provides new insights and technical support for clinical diagnosis and treatment, holding significant theoretical and practical implications.
KEY WORDS：Cat Lower Urinary Tract Syndrome；Etiological Mechanism；Gut-Urinary Axis
目 录
摘 要 I
ABSTRACT II
第一章 绪论 1
1.1 研究背景与意义 1
1.2 国内外研究现状分析 1
第二章 猫下泌尿道综合征的病因分析 2
2.1 解剖与生理基础概述 2
2.2 常见病因分类与机制 2
2.3 特殊病因的识别与评估 3
第三章 猫下泌尿道综合征的诊断技术进展 4
3.1 临床症状与初步诊断 4
3.2 实验室检测技术的应用 4
3.3 影像学检查在诊断中的作用 5
第四章 猫下泌尿道综合征的治疗策略与进展 6
4.1 药物治疗的选择与优化 6
4.2 手术干预的适应症与效果 6
4.3 预防措施与长期管理方案 7
结 论 8
参考文献 9
致 谢 10
