摘 要
慢性阻塞性肺疾病（COPD）是全球范围内常见的呼吸系统疾病，其特征为持续性气流受限且呈进行性发展，严重影响患者生活质量并增加死亡风险。长期家庭氧疗（LTOT）作为改善低氧血症的重要手段，在临床实践中广泛应用，但关于其具体效果仍需深入研究。本研究旨在评估LTOT对稳定期COPD患者的疗效及其对预后的影响。选取某三甲医院2018年1月至2021年1月期间确诊的300例COPD患者作为研究对象，按照是否接受LTOT分为实验组与对照组，每组各150例。通过回顾性分析两组患者的人口学资料、肺功能指标、血气分析结果、6分钟步行距离测试成绩以及住院次数等数据，采用SPSS 22.0软件进行统计学处理。结果显示，实验组患者在接受LTOT后动脉血氧分压显著升高，二氧化碳分压降低，FEV1%pred较治疗前有所提高，6分钟步行距离延长，急性加重频率减少，再入院率明显低于对照组。进一步研究表明，LTOT能够有效改善COPD患者的缺氧状态，延缓肺功能恶化进程，减轻症状负担，提高运动耐力，降低医疗资源消耗，具有重要的临床意义和社会价值。此外，本研究还发现合理制定个性化氧疗方案对于提升LTOT效果至关重要，这为今后优化COPD管理策略提供了新思路。
关键词：慢性阻塞性肺疾病；长期家庭氧疗；疗效评估
Abstract
Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by persistent airflow limitation and progressive development, significantly impairing patients' quality of life and increasing mortality risk. Long-term oxygen therapy (LTOT) serves as a crucial intervention for managing hypoxemia and is widely applied in clinical practice; however, its specific efficacy warrants further investigation. This study aimed to evaluate the therapeutic effects of LTOT on stable COPD patients and its impact on prognosis. A total of 300 COPD patients diagnosed between January 2018 and January 2021 at a tertiary hospital were selected and divided into an experimental group and a control group, each comprising 150 patients, based on whether they received LTOT. Retrospective analysis was conducted on demographic data, pulmonary function indices, blood gas analysis results, six-minute walk test scores, and hospitalization frequency using SPSS 22.0 for statistical processing. The findings indicated that after receiving LTOT, the arterial oxygen partial pressure of patients in the experimental group significantly increased, carbon dioxide partial pressure decreased, FEV1%pred improved compared to pre-treatment levels, six-minute walking distance extended, exacerbation frequency reduced, and readmission rates were notably lower than those in the control group. Further research demonstrated that LTOT effectively alleviated hypoxia in COPD patients, slowed the deterioration of lung function, mitigated symptom burden, enhanced exercise tolerance, and reduced healthcare resource consumption, highlighting its significant clinical and social value. Additionally, this study revealed that formulating personalized oxygen therapy protocols is critical for optimizing LTOT outcomes, providing new insights for refining COPD management strategies.
Keywords：Chronic Obstructive Pulmonary Disease；Long-Term Home Oxygen Therapy；Efficacy Evaluation
目 录
引 言 1
第一章 慢性阻塞性肺疾病概述 2
1.1 疾病流行病学特征 2
1.2 病理生理机制分析 2
1.3 临床症状与诊断标准 3
第二章 家庭氧疗的理论基础 5
2.1 氧疗原理与机制 5
2.2 家庭氧疗设备要求 5
2.3 氧疗方案制定原则 6
第三章 长期家庭氧疗效果评估方法 7
3.1 生理指标监测手段 7
3.2 生活质量评价体系 7
3.3 并发症发生率统计 8
第四章 长期家庭氧疗的实际应用效果 10
4.1 呼吸功能改善情况 10
4.2 运动耐力变化分析 10
4.3 心理状态影响研究 11
结 论 13
参考文献 14
致 谢 15
慢性阻塞性肺疾病（COPD）是全球范围内常见的呼吸系统疾病，其特征为持续性气流受限且呈进行性发展，严重影响患者生活质量并增加死亡风险。长期家庭氧疗（LTOT）作为改善低氧血症的重要手段，在临床实践中广泛应用，但关于其具体效果仍需深入研究。本研究旨在评估LTOT对稳定期COPD患者的疗效及其对预后的影响。选取某三甲医院2018年1月至2021年1月期间确诊的300例COPD患者作为研究对象，按照是否接受LTOT分为实验组与对照组，每组各150例。通过回顾性分析两组患者的人口学资料、肺功能指标、血气分析结果、6分钟步行距离测试成绩以及住院次数等数据，采用SPSS 22.0软件进行统计学处理。结果显示，实验组患者在接受LTOT后动脉血氧分压显著升高，二氧化碳分压降低，FEV1%pred较治疗前有所提高，6分钟步行距离延长，急性加重频率减少，再入院率明显低于对照组。进一步研究表明，LTOT能够有效改善COPD患者的缺氧状态，延缓肺功能恶化进程，减轻症状负担，提高运动耐力，降低医疗资源消耗，具有重要的临床意义和社会价值。此外，本研究还发现合理制定个性化氧疗方案对于提升LTOT效果至关重要，这为今后优化COPD管理策略提供了新思路。
关键词：慢性阻塞性肺疾病；长期家庭氧疗；疗效评估
Abstract
Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by persistent airflow limitation and progressive development, significantly impairing patients' quality of life and increasing mortality risk. Long-term oxygen therapy (LTOT) serves as a crucial intervention for managing hypoxemia and is widely applied in clinical practice; however, its specific efficacy warrants further investigation. This study aimed to evaluate the therapeutic effects of LTOT on stable COPD patients and its impact on prognosis. A total of 300 COPD patients diagnosed between January 2018 and January 2021 at a tertiary hospital were selected and divided into an experimental group and a control group, each comprising 150 patients, based on whether they received LTOT. Retrospective analysis was conducted on demographic data, pulmonary function indices, blood gas analysis results, six-minute walk test scores, and hospitalization frequency using SPSS 22.0 for statistical processing. The findings indicated that after receiving LTOT, the arterial oxygen partial pressure of patients in the experimental group significantly increased, carbon dioxide partial pressure decreased, FEV1%pred improved compared to pre-treatment levels, six-minute walking distance extended, exacerbation frequency reduced, and readmission rates were notably lower than those in the control group. Further research demonstrated that LTOT effectively alleviated hypoxia in COPD patients, slowed the deterioration of lung function, mitigated symptom burden, enhanced exercise tolerance, and reduced healthcare resource consumption, highlighting its significant clinical and social value. Additionally, this study revealed that formulating personalized oxygen therapy protocols is critical for optimizing LTOT outcomes, providing new insights for refining COPD management strategies.
Keywords：Chronic Obstructive Pulmonary Disease；Long-Term Home Oxygen Therapy；Efficacy Evaluation
目 录
引 言 1
第一章 慢性阻塞性肺疾病概述 2
1.1 疾病流行病学特征 2
1.2 病理生理机制分析 2
1.3 临床症状与诊断标准 3
第二章 家庭氧疗的理论基础 5
2.1 氧疗原理与机制 5
2.2 家庭氧疗设备要求 5
2.3 氧疗方案制定原则 6
第三章 长期家庭氧疗效果评估方法 7
3.1 生理指标监测手段 7
3.2 生活质量评价体系 7
3.3 并发症发生率统计 8
第四章 长期家庭氧疗的实际应用效果 10
4.1 呼吸功能改善情况 10
4.2 运动耐力变化分析 10
4.3 心理状态影响研究 11
结 论 13
参考文献 14
致 谢 15
